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Article

Single nucleotide polymorphisms and inherited risk of chronic lymphocytic leukemia among African Americans.

Blood - 23 Aug 2012

Coombs Catherine C, Rassenti Laura Z, Falchi Lorenzo, Slager Susan L, Strom Sara S, Ferrajoli Alessandra, Weinberg J Brice, Kipps Thomas J, Lanasa Mark C

Abstract excerpt

The incidence of chronic lymphocytic leukemia (CLL) is significantly lower in African Americans than whites, but overall survival is inferior. The biologic basis for these observations remains unexplored. We hypothesized that germline genetic predispositions differ between African Americans and whites with CLL and yield inferior clinical outcomes among African Americans. We examined a discovery cohort of 42...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22745306
DOI: 10.1182/blood-2012-02-408799
PMCID: PMC3429309

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