Article
Oncological evaluation in the perioperative period using cfDNA with BRAF V600E mutation in patients with colorectal cancer.
Scientific reports - 24 Jun 2021
Tanaka Keita, Yoshida Yoichiro, Yamada Teppei, Hayashi Takaomi, Shimaoka Hideki, Yoshimura Fumihiro, Kajitani Ryuji, Munechika Taro, Matsumoto Yoshiko, Nagano Hideki, Komono Akira, Sakamoto Ryohei, Nakashima Ryo, Aisu Naoya, Yoshimatsu Gumpei, Hasegawa Suguru
Abstract excerpt
The detection of circulating cell-free DNA (cfDNA) by liquid biopsy is reported to provide prognostic information in colorectal cancer (CRC). Although the frequency of BRAF V600E mutation in CRC is less than 10%, it is associated with poor responses to conventional chemotherapy. We conducted a prospective study to investigate the relationship between the perioperative mutant allele frequency (MAF) of BRAF V600E...
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