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Article

Site-Specific Mutations on KRAS, NRAS, and BRAF Corelate With the Frequency of ctDNA in Colorectal Cancer.

Cancer reports (Hoboken, N.J.) - 1 Jul 2025

Yoshimura Fumihiro, Yoshida Yoichiro, Yamada Teppei, Tanaka Keita, Hayashi Takaomi, Shimaoka Hideki, Sakamoto Ryohei, Aisu Naoya, Yoshimatsu Gumpei, Hasegawa Suguru

Abstract excerpt

BACKGROUND: Early prediction of metastatic risk after tumor resection for colorectal cancer (CRC) is critical to improve treatment outcomes. Although circulating tumor DNA (ctDNA) is an important biomarker in CRC patients, positivity is variable because cutoff values for each gene have not been clearly established. When examining the mutant allele frequency (MAF) of a gene, the cutoff value is the same for the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40698441
DOI: 10.1002/cnr2.70292
PMCID: PMC12284603

Genes

MAF
KRAS
BRAF
NRAS

Provenance

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