Article
Interaction between the type 4 pili machinery and a diguanylate cyclase fine-tune c-di-GMP levels during early biofilm formation.
Proceedings of the National Academy of Sciences of the United States of America - 29 Jun 2021
Webster Shanice S, Lee Calvin K, Schmidt William C, Wong Gerard C L, O'Toole George A
Abstract excerpt
To initiate biofilm formation, it is critical for bacteria to sense a surface and respond precisely to activate downstream components of the biofilm program. Type 4 pili (T4P) and increasing levels of c-di-GMP have been shown to be important for surface sensing and biofilm formation, respectively; however, mechanisms important in modulating the levels of this dinucleotide molecule to define a precise output...
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