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Article

The SiaA/B/C/D signaling network regulates biofilm formation in Pseudomonas aeruginosa.

The EMBO journal - 16 Mar 2020

Chen Gukui, Gan Jianhua, Yang Chun, Zuo Yili, Peng Juan, Li Meng, Huo Weiping, Xie Yingpeng, Zhang Yani, Wang Tietao, Deng Xin, Liang Haihua

Abstract excerpt

Bacterial cyclic-di-GMP (c-di-GMP) production is associated with biofilm development and the switch from acute to chronic infections. In Pseudomonas aeruginosa, the diguanylate cyclase (DGC) SiaD and phosphatase SiaA, which are co-transcribed as part of a siaABCD operon, are essential for cellular aggregation. However, the detailed functions of this operon and the relationships among its constituent genes are...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 32090355
DOI: 10.15252/embj.2019103412
PMCID: PMC7073463

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