Article
Broadcasting of amplitude- and frequency-modulated c-di-GMP signals facilitates cooperative surface commitment in bacterial lineages.
Proceedings of the National Academy of Sciences of the United States of America - 25 Jan 2022
Lee Calvin K, Schmidt William C, Webster Shanice S, Chen Jonathan W, O'Toole George A, Wong Gerard C L
Abstract excerpt
Work on surface sensing in bacterial biofilms has focused on how cells transduce sensory input into cyclic diguanylate (c-di-GMP) signaling, low and high levels of which generally correlate with high-motility planktonic cells and low-motility biofilm cells, respectively. Using Granger causal inference methods, however, we find that single-cell c-di-GMP increases are not sufficient to imply surface commitment....
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