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rigrag: high-resolution mapping of genic targeting preferences during HIV-1 integration in vitro and in vivo

22 Jun 2021

Abstract excerpt

HIV-1 integration favors recurrent integration gene (RIG) targets and genic proviruses can confer cell survival in vivo. However, the relationship between initial RIG integrants and how these evolve in patients over time are unknown. To address these shortcomings, we built phenomenological models of random integration in silico, which were used to identify 3718 RIGs as well as 2150 recurrent avoided genes from...

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PMID: 34165568
DOI: 10.1093/nar/gkab514

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