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Article

The chromatin landscape at the HIV-1 provirus integration site determines viral expression

12 Jun 2020

Abstract excerpt

HIV-1 persists lifelong in memory cells of the immune system as latent provirus that rebounds upon treatment interruption. Therefore, the latent reservoir is the main target for an HIV cure. Here, we studied the direct link between integration site and transcription using LEDGINs and Barcoded HIV-ensembles (B-HIVE). LEDGINs are antivirals that inhibit the interaction between HIV-1 integrase and the...

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PMID: 32597987
DOI: 10.1093/nar/gkaa536

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