Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Role of PSIP1/LEDGF/p75 in Lentiviral Infectivity and Integration Targeting

18 Dec 2007

Abstract excerpt

BACKGROUND: To replicate, lentiviruses such as HIV must integrate DNA copies of their RNA genomes into host cell chromosomes. Lentiviral integration is favored in active transcription units, which allows efficient viral gene expression after integration, but the mechanisms directing integration targeting are incompletely understood. A cellular protein, PSIP1/LEDGF/p75, binds tightly to the lentiviral-encoded...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to HIV/AIDS drug development and treatment
Share to HIV Research and Treatment
Share to Virus-based gene therapy research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 18092005
DOI: 10.1371/journal.pone.0001340

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Role of PSIP1/LEDGF/p75 in Lentiviral Infectivity and Integration TargetingPMID 18092005Read ↗

Differential Effects of Human Immunodeficiency Virus Type 1 Capsid and Cellular Factors Nucleoporin 153 and LEDGF/p75 on the Efficiency and Specificity of Viral DNA IntegrationSemantic proximity Read ↗

TALEN Knockout of the <i>PSIP1</i> Gene in Human Cells: Analyses of HIV-1 Replication and Allosteric Integrase Inhibitor MechanismSemantic proximity Read ↗

Transient and Stable Knockdown of the Integrase Cofactor LEDGF/p75 Reveals Its Role in the Replication Cycle of Human Immunodeficiency VirusSemantic proximity Read ↗

CPSF6-Dependent Targeting of Speckle-Associated Domains Distinguishes Primate from Nonprimate Lentiviral IntegrationSemantic proximity Read ↗

Genome-wide profiling of retroviral DNA integration and its effect on clinical pre-infusion CAR T-cell productsSemantic proximity Read ↗

Simian Immunodeficiency Virus Integration Preference Is Similar to That of Human Immunodeficiency Virus Type 1Semantic proximity Read ↗

Transcription factor binding sites are genetic determinants of retroviral integration in the human genome.Semantic proximity Read ↗

HRP-2 determines HIV-1 integration site selection in LEDGF/p75 depleted cellsSemantic proximity Read ↗

An Essential Role for LEDGF/p75 in HIV IntegrationSemantic proximity Read ↗

Virus evolution reveals an exclusive role for LEDGF/p75 in chromosomal tethering of HIV.Semantic proximity Read ↗

Genome-wide mapping of foamy virus vector integrations into a human cell lineSemantic proximity Read ↗

A critical role for alternative polyadenylation factor CPSF6 in targeting HIV-1 integration to transcriptionally active chromatin.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.