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Article

PDGF upregulates CLEC-2 to induce T regulatory cells.

Oncotarget - 6 Oct 2015

Agrawal Sudhanshu, Ganguly Sreerupa, Hajian Pega, Cao Jia-Ning, Agrawal Anshu

Abstract excerpt

The effect of platelet derived growth factor (PDGF) on immune cells is not elucidated. Here, we demonstrate PDGF inhibited the maturation of human DCs and induced IL-10 secretion. Culture of PDGF-DCs with T cells induced the polarization of T cells towards FoxP3 expressing T regulatory cells that secreted IL-10. Gene expression studies revealed that PDGF induced the expression of C-type lectin like receptor...

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Identifiers

PMID: 26416420
DOI: 10.18632/oncotarget.5765
PMCID: PMC4745681

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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