Multiparametric profiling of non-small-cell lung cancers reveals distinct immunophenotypes.

doi:10.1172/jci.insight.89014

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Article

Multiparametric profiling of non-small-cell lung cancers reveals distinct immunophenotypes.

JCI insight - 8 Sept 2016

Lizotte Patrick H, Ivanova Elena V, Awad Mark M, Jones Robert E, Keogh Lauren, Liu Hongye, Dries Ruben, Almonte Christina, Herter-Sprie Grit S, Santos Abigail, Feeney Nora B, Paweletz Cloud P, Kulkarni Meghana M, Bass Adam J, Rustgi Anil K, Yuan Guo-Cheng, Kufe Donald W, Jänne Pasi A, Hammerman Peter S, Sholl Lynette M, Hodi F Stephen, Richards William G, Bueno Raphael, English Jessie M, Bittinger Mark A, Wong Kwok-Kin

Abstract excerpt

BACKGROUND. Immune checkpoint blockade improves survival in a subset of patients with non-small-cell lung cancer (NSCLC), but robust biomarkers that predict response to PD-1 pathway inhibitors are lacking. Furthermore, our understanding of the diversity of the NSCLC tumor immune microenvironment remains limited. METHODS. We performed comprehensive flow cytometric immunoprofiling on both tumor and immune cells...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27699239
DOI: 10.1172/jci.insight.89014
PMCID: PMC5033841

Genes

EGFR
KRAS

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