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Article

Whole-genome analysis of drug-resistant Mycobacterium tuberculosis reveals novel mutations associated with fluoroquinolone resistance.

International journal of antimicrobial agents - 1 Sept 2021

Chaiyachat Pratchakan, Chaiprasert Angkana, Nonghanphithak Ditthawat, Smithtikarn Saijai, Kamolwat Phalin, Pungrassami Petchawan, Reechaipichitkul Wipa, Ong Rick Twee-Hee, Teo Yik-Ying, Faksri Kiatichai

Abstract excerpt

Multidrug-resistant and extensively drug-resistant tuberculosis (M/XDR-TB) remains a global public-health challenge. Known mutations in quinolone resistance-determination regions cannot fully explain phenotypic fluoroquinolone (FQ) resistance in Mycobacterium tuberculosis (Mtb). The aim of this study was to look for novel mutations in Mtb associated with resistance to FQ drugs using whole-genome sequencing...

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Identifiers

PMID: 34161790
DOI: 10.1016/j.ijantimicag.2021.106385

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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