Article
The Inherent Dynamics and Interaction Sites of the SARS-CoV-2 Nucleocapsid N-Terminal Region.
Journal of molecular biology - 23 Jul 2021
Redzic Jasmina S, Lee Eunjeong, Born Alexandra, Issaian Aaron, Henen Morkos A, Nichols Parker J, Blue Ashley, Hansen Kirk C, D'Alessandro Angelo, Vögeli Beat, Eisenmesser Elan Zohar
Abstract excerpt
The nucleocapsid protein is one of four structural proteins encoded by SARS-CoV-2 and plays a central role in packaging viral RNA and manipulating the host cell machinery, yet its dynamic behavior and promiscuity in nucleotide binding has made standard structural methods to address its atomic-resolution details difficult. To begin addressing the SARS-CoV-2 nucleocapsid protein interactions with both RNA and the...
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