N-Terminal mutations in SARS-CoV-2 NSP1 alter the structure and dynamics of its C-terminal disordered region, impacting mRNA translation in ribosomes: insights from molecular dynamics simulations.

Abstract excerpt

Although numerous studies have demonstrated that mutations in the N-terminal domain of SARS-CoV-2 non-structural protein 1 (NSP1) alter the C-terminal domain and affect host mRNA translation, the full mechanistic understanding of how these mutations change NSP1 behaviour remains incomplete. In this research, we employ molecular dynamics (MD) simulations to investigate the conformational effects of single-point...

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