Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Defects in Jak-STAT-mediated cytokine signals cause hyper-IgE syndrome: lessons from a primary immunodeficiency.

International immunology - 1 Feb 2009

Minegishi Yoshiyuki, Karasuyama Hajime

Abstract excerpt

Hyper-IgE syndrome (HIES) is a primary immunodeficiency characterized by atopic manifestations and susceptibility to infections with extracellular bacteria and fungi, which frequently occur in the skin and lung. Atopic manifestations in HIES include extremely high serum IgE levels, eczema and eos...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Agammaglobulinemia
Share to Immunoglobulins
Share to Interleukin-17

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Job Syndrome

Share to Opportunistic Infections

Share to STAT3 Transcription Factor

Share to T-Lymphocytes, Helper-Inducer

Share to TYK2 Kinase

Source

Identifiers

PMID: 19088064
DOI: 10.1093/intimm/dxn134

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19088064-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Defects in Jak-STAT-mediated cytokine signals cause hyper-IgE syndrome: lessons from a primary immunodeficiency.PMID 19088064Read ↗

Genetic origins of hyper-IgE syndrome.Semantic proximity Read ↗

Hyper-IgE syndrome.Semantic proximity Read ↗

Hyper IgE syndrome: an update on clinical aspects and the role of signal transducer and activator of transcription 3.Semantic proximity Read ↗

Primary Immunodeficiencies with Elevated IgE.Semantic proximity Read ↗

Mutations in STAT3 and diagnostic guidelines for hyper-IgE syndrome.Semantic proximity Read ↗

Pathogenesis of hyper IgE syndrome.Semantic proximity Read ↗

An update on the hyper-IgE syndromes.Semantic proximity Read ↗

Cutaneous manifestations of Hyper IgE syndrome.Semantic proximity Read ↗

Novel signal transducer and activator of transcription 3 (STAT3) mutations, reduced T(H)17 cell numbers, and variably defective STAT3 phosphorylation in hyper-IgE syndrome.Semantic proximity Read ↗

Hyper-IgE Syndromes and the Lung.Semantic proximity Read ↗

STAT mutations as program switchers: turning primary immunodeficiencies into autoimmune diseases.Semantic proximity Read ↗

A challenging differential diagnosis in a patient with autosomal dominant STAT3 deficiency.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.