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Human MCTS1-dependent translation of JAK2 is essential for IFN-γ immunity to mycobacteria

23 Oct 2023

Abstract excerpt

Human inherited disorders of interferon-gamma (IFN-γ) immunity underlie severe mycobacterial diseases. We report X-linked recessive MCTS1 deficiency in men with mycobacterial disease from kindreds of different ancestries (from China, Finland, Iran, and Saudi Arabia). Complete deficiency of this translation re-initiation factor impairs the translation of a subset of proteins, including the kinase JAK2 in all cell...

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PMID: 37875108
DOI: 10.1016/j.cell.2023.09.024

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