Article
Comparison of Next-Generation Sequencing-Based Human Leukocyte Antigen Typing with Clinical Flow Cytometry and Allele-Specific PCR Melting Assays for HLA-B27 Genotyping.
The journal of applied laboratory medicine - 1 Sept 2021
Profaizer Tracie, Dibb Kimberly, Bethers Holly, Monds Cassandra, Andreasen John, Delgado Julio C, Lázár-Molnár Eszter
Abstract excerpt
BACKGROUND: Due to the strong association between ankylosing spondylitis and Human Leukocyte Antigen (HLA)-B27, accurate identification of HLA-B27 is important in the diagnosis of patients with suspected spondyloarthritides. For this study, we compared a high-resolution HLA-B typing method to the clinical flow cytometry and allele-specific PCR melting assays to determine clinical benefits of high-resolution...
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