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Article

Novel Anaplastic Thyroid Cancer PDXs and Cell Lines: Expanding Preclinical Models of Genetic Diversity.

The Journal of clinical endocrinology and metabolism - 21 Oct 2021

Maniakas Anastasios, Henderson Ying C, Hei Hu, Peng Shaohua, Chen Yunyun, Jiang Yujie, Ji Shuangxi, Cardenas Maria, Chiu Yulun, Bell Diana, Williams Michelle D, Hofmann Marie-Claude, Scherer Steve E, Wheeler David A, Busaidy Naifa L, Dadu Ramona, Wang Jennifer R, Cabanillas Maria E, Zafereo Mark, Johnson Faye M, Lai Stephen Y

Abstract excerpt

CONTEXT: Anaplastic thyroid cancer (ATC) is a rare, aggressive, and deadly disease. Robust preclinical thyroid cancer models are needed to adequately develop and study novel therapeutic agents. Patient-derived xenograft (PDX) models may resemble patient tumors by recapitulating key genetic alterations and gene expression patterns, making them excellent preclinical models for drug response evaluation. OBJECTIVE:...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Thyroid Carcinoma, Anaplastic

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Source

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Identifiers

PMID: 34147031
DOI: 10.1210/clinem/dgab453
PMCID: PMC8530744

Genes

BRAF
TP53
CDKN2A
TERT
HRAS
KRAS
NF2
NFE2L2
PAX8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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