Article
Methodology, Criteria, and Characterization of Patient-Matched Thyroid Cell Lines and Patient-Derived Tumor Xenografts.
The Journal of clinical endocrinology and metabolism - 1 Sept 2018
Marlow Laura A, Rohl Stephen D, Miller James L, Knauf Jeffery A, Fagin James A, Ryder Mabel, Milosevic Dragana, Netzel Brian C, Grebe Stefan K, Reddi Honey V, Smallridge Robert C, Copland John A
Abstract excerpt
Objective: To investigate the molecular underpinnings of thyroid cancer, preclinical cell line models are crucial; however, ∼40% of these have been proven to be either duplicates of existing thyroid lines or even nonthyroid-derived lines or are not derived from humans at all. Therefore, we set out to establish procedures and guidelines that should proactively avoid these problems, which facilitated the creation...
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