Article
Landscape of IDH1/2 mutations in Chinese patients with solid tumors: A pan-cancer analysis.
Molecular genetics & genomic medicine - 1 Aug 2021
Shen Dong, Zhang Junling, Yuan Kai, Zhao Jing, Zhao Zhengyi, Cui Longgang, Zhang Yuzi, Wang Guoqiang, Cai Shangli, Bai Yuezong, Li Wei, Huang Xiang
Abstract excerpt
BACKGROUND: Isocitrate dehydrogenase (IDH) is an enzyme family involved in cell aerobic metabolism of tricarboxylic acid cycle. However, the landscape of IDH mutations in pan-cancer has not been fully characterized. METHODS: Tissue or blood samples were subjected to next-generation sequencing (NGS) for detection the IDH mutation. RESULTS: A total of 28.868 patients from more than 20 solid tumor species were...
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