Article
Upregulation of cell surface GD3 ganglioside phenotype is associated with human melanoma brain metastasis.
Molecular oncology - 1 Aug 2020
Ramos Romela Irene, Bustos Matias A, Wu Jinfeng, Jones Peter, Chang Shu Ching, Kiyohara Eiji, Tran Kevin, Zhang Xiaoqing, Stern Stacey L, Izraely Sivan, Sagi-Assif Orit, Witz Isaac P, Davies Michael A, Mills Gordon B, Kelly Daniel F, Irie Reiko F, Hoon Dave S B
Abstract excerpt
Melanoma metastasis to the brain is one of the most frequent extracranial brain tumors. Cell surface gangliosides are elevated in melanoma metastasis; however, the metabolic regulatory mechanisms that govern these specific changes are poorly understood in melanoma particularly brain metastases (MBM) development. We found ganglioside GD3 levels significantly upregulated in MBM compared to lymph node metastasis...
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