Article
Redox system expression in the motor neurons in amyotrophic lateral sclerosis (ALS): immunohistochemical studies on sporadic ALS, superoxide dismutase 1 (SOD1)-mutated familial ALS, and SOD1-mutated ALS animal models.
Acta neuropathologica - 1 Aug 2005
Kato Shinsuke, Kato Masako, Abe Yasuko, Matsumura Tomohiro, Nishino Takeshi, Aoki Masashi, Itoyama Yasuto, Asayama Kohtaro, Awaya Akira, Hirano Asao, Ohama Eisaku
Abstract excerpt
Peroxiredoxin-ll (Prxll) and glutathione peroxidase-l (GPxl) are regulators of the redox system that is one of the most crucial supporting systems in neurons. This system is an antioxidant enzyme defense system and is synchronously linked to other important cell supporting systems. To clarify the common self-survival mechanism of the residual motor neurons affected by amyotrophic lateral sclerosis (ALS), we...
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