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Research Models to Study Ferroptosis’s Impact in Neurodegenerative Diseases

29 Apr 2023

Abstract excerpt

Ferroptosis is a type of regulated cell death promoted by the appearance of oxidative perturbations in the intracellular microenvironment constitutively controlled by glutathione peroxidase 4 (GPX4). It is characterized by increased production of reactive oxygen species, intracellular iron accumulation, lipid peroxidation, inhibition of system Xc-, glutathione depletion, and decreased GPX4 activity. Several...

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PMID: 37242612
DOI: 10.3390/pharmaceutics15051369

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