Article
Breast-Specific Molecular Clocks Comprised of ELF5 Expression and Promoter Methylation Identify Individuals Susceptible to Cancer Initiation.
Cancer prevention research (Philadelphia, Pa.) - 1 Aug 2021
Miyano Masaru, Sayaman Rosalyn W, Shalabi Sundus F, Senapati Parijat, Lopez Jennifer C, Angarola Brittany Lynn, Hinz Stefan, Zirbes Arrianna, Anczukow Olga, Yee Lisa D, Sedrak Mina S, Stampfer Martha R, Seewaldt Victoria L, LaBarge Mark A
Abstract excerpt
A robust breast cancer prevention strategy requires risk assessment biomarkers for early detection. We show that expression of ELF5, a transcription factor critical for normal mammary development, is downregulated in mammary luminal epithelia with age. DNA methylation of the ELF5 promoter is negatively correlated with expression in an age-dependent manner. Both ELF5 methylation and gene expression were used to...
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