ELF5 suppresses estrogen sensitivity and underpins the acquisition of antiestrogen resistance in luminal breast cancer.

doi:10.1371/journal.pbio.1001461

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Article

ELF5 suppresses estrogen sensitivity and underpins the acquisition of antiestrogen resistance in luminal breast cancer.

PLoS biology - 1 Jan 2012

Kalyuga Maria, Gallego-Ortega David, Lee Heather J, Roden Daniel L, Cowley Mark J, Caldon C Elizabeth, Stone Andrew, Allerdice Stephanie L, Valdes-Mora Fatima, Launchbury Rosalind, Statham Aaron L, Armstrong Nicola, Alles M Chehani, Young Adelaide, Egger Andrea, Au Wendy, Piggin Catherine L, Evans Cara J, Ledger Anita, Brummer Tilman, Oakes Samantha R, Kaplan Warren, Gee Julia M W, Nicholson Robert I, Sutherland Robert L, Swarbrick Alexander, Naylor Matthew J, Clark Susan J, Carroll Jason S, Ormandy Christopher J

Abstract excerpt

We have previously shown that during pregnancy the E-twenty-six (ETS) transcription factor ELF5 directs the differentiation of mammary progenitor cells toward the estrogen receptor (ER)-negative and milk producing cell lineage, raising the possibility that ELF5 may suppress the estrogen sensitivity of breast cancers. To test this we constructed inducible models of ELF5 expression in ER positive luminal breast...

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Identifiers

PMID: 23300383
DOI: 10.1371/journal.pbio.1001461
PMCID: PMC3531499

Genes

ELF5
FOXA1
EGFR
MYC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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