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Article

Methylation-Based Biological Age and Breast Cancer Risk

17 Feb 2019

Abstract excerpt

BACKGROUND: Age is one of the strongest predictors of cancer, chronic disease, and mortality, but biological responses to aging differ among people. Epigenetic DNA modifications have been used to estimate "biological age," which may be a useful predictor of disease risk. We tested this hypothesis for breast cancer. METHODS: Using a case-cohort approach, we measured baseline blood DNA methylation of 2764 women...

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PMID: 30794318
DOI: 10.1093/jnci/djz020

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