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CRISPR/Cas12a mediated knock-in of the Polled Celtic variant to produce a polled genotype in dairy cattle.

Scientific reports - 11 Aug 2020

Schuster Felix, Aldag Patrick, Frenzel Antje, Hadeler Klaus-Gerd, Lucas-Hahn Andrea, Niemann Heiner, Petersen Björn

Abstract excerpt

In modern livestock farming horned cattle pose an increased risk of injury for each other as well as for the farmers. Dehorning without anesthesia is associated with stress and pain for the calves and raises concerns regarding animal welfare. Naturally occurring structural variants causing polledness are known for most beef cattle but are rare within the dairy cattle population. The most common structural variant...

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PMID: 32782385
DOI: 10.1038/s41598-020-70531-y
PMCID: PMC7419524

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