Article
Sensitive period for rescuing parvalbumin interneurons connectivity and social behavior deficits caused by TSC1 loss.
Nature communications - 16 Jun 2021
Amegandjin Clara A, Choudhury Mayukh, Jadhav Vidya, Carriço Josianne Nunes, Quintal Ariane, Berryer Martin, Snapyan Marina, Chattopadhyaya Bidisha, Saghatelyan Armen, Di Cristo Graziella
Abstract excerpt
The Mechanistic Target Of Rapamycin Complex 1 (mTORC1) pathway controls several aspects of neuronal development. Mutations in regulators of mTORC1, such as Tsc1 and Tsc2, lead to neurodevelopmental disorders associated with autism, intellectual disabilities and epilepsy. The correct development of inhibitory interneurons is crucial for functional circuits. In particular, the axonal arborisation and synapse...
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