Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

GABAergic Interneuron Development and Function Is Modulated by the Tsc1 Gene

20 Oct 2011

Abstract excerpt

Tuberous sclerosis complex (TSC) is a genetic disease with severe neurologic and psychiatric manifestations including epilepsy, developmental delay, and autism. Despite much progress in defining abnormal signaling pathways including the contribution of increased mTORC1 signaling, specific abnormalities that underlie the severe neurologic features in TSC remain poorly understood. We hypothesized that epilepsy and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Mast cells and histamine
Share to PI3K/AKT/mTOR signaling in cancer
Share to Tuberous Sclerosis Complex Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 22021912
DOI: 10.1093/cercor/bhr300

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

GABAergic Interneuron Development and Function Is Modulated by the Tsc1 GenePMID 22021912Read ↗

Synaptic hyperexcitability of cytomegalic pyramidal neurons contributes to epileptogenesis in tuberous sclerosis complexSemantic proximity Read ↗

A human <i>TSC1</i> mutation screening platform in GABAergic cortical interneurons for Genotype to Phenotype assessmentsSemantic proximity Read ↗

A Mouse Model of Tuberous Sclerosis: Neuronal Loss of Tsc1 Causes Dysplastic and Ectopic Neurons, Reduced Myelination, Seizure Activity, and Limited SurvivalSemantic proximity Read ↗

Brain Symptoms of Tuberous Sclerosis Complex: Pathogenesis and Treatment.Semantic proximity Read ↗

Sensitive period for rescuing parvalbumin interneurons connectivity and social behavior deficits caused by TSC1 loss.Semantic proximity Read ↗

A circuitry and biochemical basis for tuberous sclerosis symptoms: from epilepsy to neurocognitive deficitsSemantic proximity Read ↗

Tsc2 gene inactivation causes a more severe epilepsy phenotype than Tsc1 inactivation in a mouse model of tuberous sclerosis complex.Semantic proximity Read ↗

Single-cell Tsc1 knockout during corticogenesis generates tuber-like lesions and reduces seizure threshold in miceSemantic proximity Read ↗

Complex Neurological Phenotype in Mutant Mice Lacking Tsc2 in Excitatory Neurons of the Developing Forebrain(123).Semantic proximity Read ↗

Tuberous sclerosis complex and epilepsy: recent developments and future challenges.Semantic proximity Read ↗

mTOR signaling in epilepsy: insights from malformations of cortical development.Semantic proximity Read ↗

Genetic Etiologies, Diagnosis, and Treatment of Tuberous Sclerosis ComplexSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.