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Article

Brain Symptoms of Tuberous Sclerosis Complex: Pathogenesis and Treatment.

International journal of molecular sciences - 22 Jun 2021

Mizuguchi Masashi, Ohsawa Maki, Kashii Hirofumi, Sato Atsushi

Abstract excerpt

The mammalian target of the rapamycin (mTOR) system plays multiple, important roles in the brain, regulating both morphology, such as cellular size, shape, and position, and function, such as learning, memory, and social interaction. Tuberous sclerosis complex (TSC) is a congenital disorder caused by a defective suppressor of the mTOR system, the TSC1/TSC2 complex. Almost all brain symptoms of TSC are...

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Source

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Identifiers

PMID: 34206526
DOI: 10.3390/ijms22136677
PMCID: PMC8268912

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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