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Article

Hydrogen sulfide promotes angiogenesis by downregulating miR-640 via the VEGFR2/mTOR pathway.

American journal of physiology. Cell physiology - 15 Feb 2016

Zhou Yu, Li Xing-Hui, Zhang Cai-Cai, Wang Ming-Jie, Xue Wen-Long, Wu Dong-Dong, Ma Fen-Fen, Li Wen-Wen, Tao Bei-Bei, Zhu Yi-Chun

Abstract excerpt

We previously found hydrogen sulfide (H2S) to be a new proangiogenic factor. However, the mechanisms underlying the cardiovascular effect of this small gas molecule remain largely unknown. The aim of the present study was to identify the essential microRNAs (miRNAs) involved in the transduction of H2S signals in vascular endothelial cells (ECs). The expression of miR-640 and its signaling elements, vascular...

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PMID: 26879375
DOI: 10.1152/ajpcell.00230.2015

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