Article
Atherosclerotic lesion size and vulnerability are determined by patterns of fluid shear stress.
Circulation - 13 Jun 2006
Cheng Caroline, Tempel Dennie, van Haperen Rien, van der Baan Arjen, Grosveld Frank, Daemen Mat J A P, Krams Rob, de Crom Rini
Abstract excerpt
BACKGROUND: Atherosclerotic lesions are predominantly observed in curved arteries and near side branches, where low or oscillatory shear stress patterns occur, suggesting a causal connection. However, the effect of shear stress on plaque vulnerability is unknown because the lack of an appropriate in vivo model precludes cause-effect studies. METHODS AND RESULTS: We developed a perivascular shear stress modifier...
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