Article
Novel mutation in ODF2 causes multiple morphological abnormalities of the sperm flagella in an infertile male.
Asian journal of andrology - 1 Jan 2000
Zhu Zi-Jue, Wang Yi-Zhou, Wang Xiao-Bo, Yao Chen-Cheng, Zhao Liang-Yu, Zhang Zhen-Bo, Wu Yu, Chen Wei, Li Zheng
Abstract excerpt
Numerous genes have been associated with multiple morphological abnormalities of the sperm flagella (MMAF), which cause severe asthenozoospermia and lead to male infertility, while the causes of approximately 50% of MMAF cases remain unclear. To reveal the genetic causes of MMAF in an infertile patient, whole-exome sequencing was performed to screen for pathogenic genes, and electron microscope was used to reveal...
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