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Article

Loss of p21-activated kinase Mbt/PAK4 causes Parkinson-like phenotypes in Drosophila.

Disease models & mechanisms - 1 Jun 2021

Pütz Stephanie M, Kram Jette, Rauh Elisa, Kaiser Sophie, Toews Romy, Lueningschroer-Wang Yi, Rieger Dirk, Raabe Thomas

Abstract excerpt

Parkinson's disease (PD) provokes bradykinesia, resting tremor, rigidity and postural instability, and also non-motor symptoms such as depression, anxiety, sleep and cognitive impairments. Similar phenotypes can be induced in Drosophila melanogaster through modification of PD-relevant genes or the administration of PD-inducing toxins. Recent studies correlated deregulation of human p21-activated kinase 4 (PAK4)...

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Identifiers

PMID: 34125184
DOI: 10.1242/dmm.047811
PMCID: PMC8246267

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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