Article
Parkinson phenotype in aged PINK1-deficient mice is accompanied by progressive mitochondrial dysfunction in absence of neurodegeneration.
PloS one - 3 Jun 2009
Gispert Suzana, Ricciardi Filomena, Kurz Alexander, Azizov Mekhman, Hoepken Hans-Hermann, Becker Dorothea, Voos Wolfgang, Leuner Kristina, Müller Walter E, Kudin Alexei P, Kunz Wolfram S, Zimmermann Annabelle, Roeper Jochen, Wenzel Dirk, Jendrach Marina, García-Arencíbia Moisés, Fernández-Ruiz Javier, Huber Leslie, Rohrer Hermann, Barrera Miguel, Reichert Andreas S, Rüb Udo, Chen Amy, Nussbaum Robert L, Auburger Georg
Abstract excerpt
BACKGROUND: Parkinson's disease (PD) is an adult-onset movement disorder of largely unknown etiology. We have previously shown that loss-of-function mutations of the mitochondrial protein kinase PINK1 (PTEN induced putative kinase 1) cause the recessive PARK6 variant of PD. METHODOLOGY/PRINCIPAL FINDINGS: Now we generated a PINK1 deficient mouse and observed several novel phenotypes: A progressive reduction of...
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