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Article

Effects of MUL1 and PARKIN on the circadian clock, brain and behaviour in Drosophila Parkinson’s disease models

28 May 2019

Abstract excerpt

BACKGROUND: Mutants which carry mutations in genes encoding mitochondrial ligases MUL1 and PARKIN are convenient Drosophila models of Parkinson's disease (PD). In several studies it has been shown that in Parkinson's disease sleep disturbance occurs, which may be the result of a disturbed circadian clock. RESULTS: mutants than in the white mutant used as a control. Moreover, mutations of both ligases affected...

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PMID: 31138137
DOI: 10.1186/s12868-019-0506-8

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