Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Analysis of the genomic landscape of yolk sac tumors reveals mechanisms of evolution and chemoresistance.

Nature communications - 11 Jun 2021

Zong Xuan, Zhang Ying, Peng Xinxin, Cao Dongyan, Yu Mei, Wang Jinhui, Li Hongyue, Guo Xuejiao, Liang Han, Yang Jiaxin

Abstract excerpt

Yolk sac tumors (YSTs) are a major histological subtype of malignant ovarian germ cell tumors with a relatively poor prognosis. The molecular basis of this disease has not been thoroughly characterized at the genomic level. Here we perform whole-exome and RNA sequencing on 41 clinical tumor samples from 30 YST patients, with distinct responses to cisplatin-based chemotherapy. We show that microsatellite...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Computational Biology
Share to DNA Copy Number Variations

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Resistance, Neoplasm

Share to Exome Sequencing

Share to Gonadal Dysgenesis

Share to Neoplasms, Germ Cell and Embryonal

Share to Ovarian Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 34117242
DOI: 10.1038/s41467-021-23681-0
PMCID: PMC8196104

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Analysis of the genomic landscape of yolk sac tumors reveals mechanisms of evolution and chemoresistance.PMID 34117242Read ↗

Molecular Characterization of Ovarian Yolk Sac Tumor (OYST)Semantic proximity Read ↗

Molecular Biology of Pediatric and Adult Ovarian Germ Cell Tumors: A ReviewSemantic proximity Read ↗

Clinicopathologic and Molecular Analysis of Malignant Neoplasms With Yolk Sac Tumor Differentiation in Women 40 Years of Age and OlderSemantic proximity Read ↗

Whole-exome sequencing reveals potential germline and somatic mutations in 60 malignant ovarian germ cell tumors†.Semantic proximity Read ↗

Molecular stratification of endometrioid ovarian carcinoma predicts clinical outcomeSemantic proximity Read ↗

Molecular stratification of endometrioid ovarian carcinoma predicts clinical outcome.Semantic proximity Read ↗

Molecular Pathways and Targeted Therapies for Malignant Ovarian Germ Cell Tumors and Sex Cord–Stromal Tumors: A Contemporary ReviewSemantic proximity Read ↗

An integrated molecular profile of endometrioid ovarian cancerSemantic proximity Read ↗

Chromosome instability region analysis and identification of the driver genes of the epithelial ovarian cancer cell lines A2780 and SKOV3Semantic proximity Read ↗

Mutational heterogeneity in non-serous ovarian cancers.Semantic proximity Read ↗

High grade serous ovarian carcinomas originate in the fallopian tube.Semantic proximity Read ↗

Mutational landscape of uterine and ovarian carcinosarcomas implicates histone genes in epithelial-mesenchymal transition.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.