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Article

Clinicopathologic and Molecular Analysis of Malignant Neoplasms With Yolk Sac Tumor Differentiation in Women 40 Years of Age and Older.

The American journal of surgical pathology - 1 Jul 2025

Numan Tricia A, Ronnett Brigitte M, Haley Lisa, Pallavajjala Aparna, Murry Jaclyn B, Kohn Jaden, Galbo Phillip M, Vang Russell, Rodriguez Fausto J, Kaur Harsimar, Levinson Kimberly, Lin Jeffrey, Palsgrove Doreen N

Abstract excerpt

Gynecologic yolk sac tumors (YSTs) are more commonly encountered in children and young women as pure or mixed germ cell tumors and are rarely observed in older women. YSTs in older women are sometimes accompanied by a Müllerian-type carcinoma component, indicating a likely somatic rather than germ-cell origin. Studies of YSTs of germ cell and somatic types in this age group are limited. Analysis of additional...

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Identifiers

PMID: 40202333
DOI: 10.1097/PAS.0000000000002389

Genes

TP53
ARID1A
ARID1B
CTNNB1
DICER1
FGFR2
KMT2C
KRAS
PMS1
PTEN
PTPRT

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