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Quantification of Osteoclasts in Culture, Powered by Machine Learning

25 May 2021

Abstract excerpt

In vitro osteoclastogenesis is a central assay in bone biology to study the effect of genetic and pharmacologic cues on the differentiation of bone resorbing osteoclasts. To date, identification of TRAP+ multinucleated cells and measurements of osteoclast number and surface rely on a manual tracing requiring specially trained lab personnel. This task is tedious, time-consuming, and prone to operator bias. Here,...

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PMID: 34113621
DOI: 10.3389/fcell.2021.674710

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