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Article

Cell morphology as a biological fingerprint of chondrocyte phenotype in control and inflammatory conditions.

Frontiers in immunology - 1 Jan 2023

Selig Mischa, Azizi Saman, Walz Kathrin, Lauer Jasmin C, Rolauffs Bernd, Hart Melanie L

Abstract excerpt

Introduction: Little is known how inflammatory processes quantitatively affect chondrocyte morphology and how single cell morphometric data could be used as a biological fingerprint of phenotype. Methods: We investigated whether trainable high-throughput quantitative single cell morphology profiling combined with population-based gene expression analysis can be used to identify biological fingerprints that are...

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Identifiers

PMID: 36860844
DOI: 10.3389/fimmu.2023.1102912
PMCID: PMC9968733

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