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Article

SorCS3 promotes the internalization of p75NTR to inhibit GBM progression

7 Apr 2022

Abstract excerpt

Abstract Glioblastoma (GBM) is a fatal malignancy caused by dysregulation of cellular signal transduction. Internalization plays a key role in maintaining signalling balance. Previous reports showed that Sortilin related VPS10 domain containing receptor 3 (SorCS3) has the ability to regulate internalization. However, the impacts of SorCS3 on the biological processes involved in GBM have not yet been reported. In...

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PMID: 35393432
DOI: 10.1038/s41419-022-04753-5

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