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Article

Anti-PD-1 elicits regression of undifferentiated pleomorphic sarcomas with UV-mutation signatures.

Journal for immunotherapy of cancer - 1 Jun 2021

Cheung Laurene S, Chen Lingling, Oke Teniola F, Schaffer Thomas B, Boudadi Karim, Ngo Jillian T, Gross John McMahon, Kemberling Holly, Diaz Luis A, Lipson Evan, Sidhom John-WIlliam, Taube Janis, Anders Robert, Pardoll Drew M, Le Dung T, Meyer Christian F, Llosa Nicolas

Abstract excerpt

Undifferentiated pleomorphic sarcoma (UPS), an aggressive soft-tissue sarcoma of adults, has been characterized by low tumor mutational burden (TMB) and high copy number alterations. Clinical trials of programmed death-1 (PD-1) blockade in UPS have reported widely varying efficacy. We describe two patients with recurrent scalp UPS that experienced clinical benefit from PD-1 blockade. These tumors had high TMB...

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Identifiers

PMID: 34103354
DOI: 10.1136/jitc-2021-002345
PMCID: PMC8190056

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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