Article

Comparative oncology reveals DNMT3B as a molecular vulnerability in soft-tissue sarcoma

2021-12-23

Abstract excerpt

<h4>ABSTRACT</h4> Undifferentiated pleomorphic sarcoma (UPS), an aggressive subtype of soft-tissue sarcoma (STS), is exceedingly rare in humans and lacks effective, well-tolerated therapies. In contrast, STS are relatively common in canine companion animals; thus, incorporation of veterinary patients into studies of UPS offers an exciting opportunity to develop novel therapeutic strategies for this rare human dis...

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Literature Corpus work: f989d9a2-d953-59ca-bc52-54bd9a7e833f
DOI: 10.1101/2021.12.22.473852

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