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Article

Pleomorphic Liposarcoma: Comprehensive Genomic Analysis of 39 Cases With Comparison to Other Genomically Complex Sarcomas.

Genes, chromosomes & cancer - 1 Sept 2026

Yakoub Mohamed A, Saoud Carla, Kim David, Dickson Mark A, Crago Aimee M, Hameed Meera, Agaram Narasimhan P

Abstract excerpt

Pleomorphic liposarcoma (PLPS) is an aggressive high-grade sarcoma that often shows diverse morphological features and can mimic high-grade undifferentiated pleomorphic sarcoma (UPS)/spindle cell sarcoma or myxofibrosarcoma (MFS), especially when pleomorphic lipoblasts are sparse. The molecular profile of PLPS is distinct from well differentiated/dedifferentiated liposarcoma and myxoid liposarcoma. In this study,...

Read the complete abstract on PubMed

Topics

Humans
Female
Liposarcoma
Aged
Male
Middle Aged
Adult

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Sarcoma

Genomics

Fibrosarcoma

Ubiquitin-Protein Ligases

Tumor Suppressor Protein p53

Biomarkers, Tumor

Mutation

Source

Open in PubMed Open full text

Identifiers

PMID: 42678048
DOI: 10.1002/gcc.70166
PMCID: PMC13531730

Genes

RB1
TP53
ATRX
CDKN2A
CYSLTR2
MYC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 22 Oct 2026.

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