Article

Heterogeneity of Undifferentiated Pleomorphic Sarcoma Genetic Landscape: Is There a Room for Targeted Therapy?

2025-09-12

Abstract excerpt

Undifferentiated pleomorphic sarcoma (UPS) is the most morphologically and genetically heterogeneous subtype of soft tissue sarcoma. UPS could harbor multiple genetic abnormalities including activating and inactivating mutations, amplifications, chromosomal translocation, variations in the copy number of different genes. Along with less widely described epigenetic changes, multiple genetic aberrations result in nu...

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Literature Corpus work: 3d30ef3d-19cf-56c7-929d-2f8df30a9758
DOI: 10.20944/preprints202509.1095.v1

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