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Article

Integrative Analysis of Pleomorphic Dermal Sarcomas Reveals Fibroblastic Differentiation and Susceptibility to Immunotherapy.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Nov 2020

Klein Sebastian, Quaas Alexander, Noh Ka-Won, Cartolano Maria, Abedpour Nima, Mauch Cornelia, Quantius Jennifer, Reinhardt Hans Christian, Buettner Reinhard, Peifer Martin, Helbig Doris

Abstract excerpt

PURPOSE: Pleomorphic dermal sarcoma (PDS) is a rare malignant cutaneous tumor with an unknown cell of origin. Locally defined tumors can be treated by curative excisions, whereas advanced stages of the disease are difficult to treat, using standard regimens. EXPERIMENTAL DESIGN: We performed whole-exome sequencing on a cohort of 28 individuals and corresponding transcriptomic analysis on 21 patients, as well as...

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Identifiers

PMID: 32817080
DOI: 10.1158/1078-0432.CCR-20-1899

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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