Article
Experimental models of undifferentiated pleomorphic sarcoma and malignant peripheral nerve sheath tumor.
Laboratory investigation; a journal of technical methods and pathology - 1 Jun 2022
Bhalla Angela D, Landers Sharon M, Singh Anand K, Landry Jace P, Yeagley Michelle G, Myerson Gabryella S B, Delgado-Baez Cristian B, Dunnand Stephanie, Nguyen Theresa, Ma Xiaoyan, Bolshakov Svetlana, Menegaz Brian A, Lamhamedi-Cherradi Salah-Eddine, Mao Xizeng, Song Xingzhi, Lazar Alexander J, McCutcheon Ian E, Slopis John M, Ludwig Joseph A, Lev Dina C, Rai Kunal, Torres Keila E
Abstract excerpt
Undifferentiated pleomorphic sarcoma (UPS) and malignant peripheral nerve sheath tumor (MPNST) are aggressive soft tissue sarcomas that do not respond well to current treatment modalities. The limited availability of UPS and MPNST cell lines makes it challenging to identify potential therapeutic targets in a laboratory setting. Understanding the urgent need for improved treatments for these tumors and the limited...
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