Article
Cardiovascular risk in cognitively preserved elderlies is associated with glucose hypometabolism in the posterior cingulate cortex and precuneus regardless of brain atrophy and apolipoprotein gene variations.
Age (Dordrecht, Netherlands) - 1 Jun 2013
Tamashiro-Duran Jaqueline Hatsuko, Squarzoni Paula, de Souza Duran Fábio Luís, Curiati Pedro Kallas, Vallada Homero Pinto, Buchpiguel Carlos Alberto, Lotufo Paulo Andrade, Wajngarten Mauricio, Menezes Paulo Rossi, Scazufca Márcia, de Toledo Ferraz Alves Tânia Corrêa, Busatto Geraldo Filho
Abstract excerpt
Cardiovascular risk factors (CVRF) possibly contribute to the emergence of Alzheimer's disease (AD). Fluorodeoxyglucose-positron emission tomography (FDG-PET) has been widely used to demonstrate specific patterns of reduced cerebral metabolic rates of glucose (CMRgl) in subjects with AD and in non-demented carriers of the apolipoprotein ε4 (APOE ε4) allele, the major genetic risk factor for AD. However,...
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