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Article

Intracerebellar transplantation of neural stem cells into mice with neurodegeneration improves neuronal networks with functional synaptic transmission.

The Journal of veterinary medical science - 1 Aug 2010

Lee Ji Min, Bae Jae-Sung, Jin Hee Kyung

Abstract excerpt

Recent studies have shown that many kinds of stem cells are beneficial for patients suffering with neurodegenerative diseases. We investigated the effects of neural stem cell (NSC), Maudsley hippocampal clone 36 (MHP36) in the Niemann-Pick disease type C (NP-C) model mice. Herein, we demonstrate that MHP36 transplantation improves the neuropathological features without acute immune response and promotes neuronal...

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PMID: 20339259
DOI: 10.1292/jvms.09-0514

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