Article
Different prion disease phenotypes result from inoculation of cattle with two temporally separated sources of sheep scrapie from Great Britain.
BMC veterinary research - 17 Oct 2006
Konold Timm, Lee Yoon Hee, Stack Michael J, Horrocks Claire, Green Robert B, Chaplin Melanie, Simmons Marion M, Hawkins Steve A C, Lockey Richard, Spiropoulos John, Wilesmith John W, Wells Gerald A H
Abstract excerpt
BACKGROUND: Given the theoretical proposal that bovine spongiform encephalopathy (BSE) could have originated from sheep scrapie, this study investigated the pathogenicity for cattle, by intracerebral (i.c.) inoculation, of two pools of scrapie agents sourced in Great Britain before and during the BSE epidemic. Two groups of ten cattle were each inoculated with pools of brain material from sheep scrapie cases...
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